Paolo Sassone-Corsi, Ph.D. is Donald Bren Professor and Director of the Center for Epigenetics and Metabolism at the University of California, Irvine. Before his move to California in 2006, he was Directeur de Recherche at the CNRS, Strasbourg, France. After graduating in Genetics at the University of Naples, Italy, he went on to two post-doctoral trainings, the first at the Universite Louis Pasteur, Strasbourg, France and then at The Salk Institute, San Diego, California. He is also External Member of the Max-Planck Institute (Germany).
Sassone-Corsi's major interest is concentrated on the mechanisms of signal transduction able to modulate nuclear functions and, in particular gene expression, chromatin remodeling and epigenetic control. His laboratory studies the molecular control of circadian rhythms and the links between cellular metabolism and epigenetics. Recent findings include the deciphering of the molecular mechanisms that connect homeostatic changes in metabolism with the mammalian circadian system. These include the effect of nutritional challenges as well as the role played by deacetylases and histone methyltransferases in the dynamic control of chromatin remodeling and nuclear organization.
Sassone-Corsi has received many awards, including the EMBO Gold Medal, the Charles-Leopold Mayer Prize of the Academie des Sciences (France) and the Ipsen Award for Endocrinology (USA).
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